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2009273-71-4

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2009273-71-4 Structure

2009273-71-4 Structure
IdentificationBack Directory
[Name]

GEN6776
[CAS]

2009273-71-4
[Synonyms]

CS-2823
GEN6776
GNE-6776
GEN6776 GNE-6776
6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide
[3,3'-Bipyridine]-6-carboxamide, 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-
5-[6-Amino-4-ethyl-5-(4-hydroxyphenyl)pyridin-3-yl]-N-methylpyridine-2-carboxamide
[Molecular Formula]

C20H20N4O2
[MDL Number]

MFCD31657364
[MOL File]

2009273-71-4.mol
[Molecular Weight]

348.4
Chemical PropertiesBack Directory
[Boiling point ]

609.7±55.0 °C(Predicted)
[density ]

1.242±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : ≥ 310 mg/mL (889.78 mM)
[form ]

Solid
[pka]

8.14±0.15(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

GNE6776, is a selective USP7 inhibitor.
[in vivo]

GNE-6776 (100 or 200 mg/kg; oral gavage on a once or twice daily schedule; for 10 days) inhibits EOL-1 xenograft growth in mice[1].

Animal Model:Immunodeficient C.B-17 SCID mice (aged 12-16 weeks) with EOL1 AML xenograft[1]
Dosage:100 or 200?mg/kg
Administration:Oral gavage on a once or twice daily schedule; for 10 days
Result:Significant EOL-1 xenograft growth inhibition.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

GEN6776(2009273-71-4)1HNMR
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