| Identification | Back Directory | [Name]
ER-27319 | [CAS]
201010-95-9 | [Synonyms]
ER 27319 MALEATE
10-(3-AMINOPROPYL)-3,4-DIMETHYL-9(10H)-ACRIDINONE MALEATE | [Molecular Formula]
C22H24N2O5 | [MDL Number]
MFCD08703129 | [MOL File]
201010-95-9.mol | [Molecular Weight]
396.436 |
| Chemical Properties | Back Directory | [Melting point ]
135 - 137°C | [storage temp. ]
2-8°C | [solubility ]
DMSO: 28 mg/mL | [form ]
solid | [color ]
Pale Yellow to Light Yellow | [InChI]
1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6) | [InChIKey]
IIELZHYJYZBSGG-UHFFFAOYSA-N | [SMILES]
OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
21/22 | [Safety Statements ]
24/25 | [WGK Germany ]
1 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Uses]
ER 27319 Maleate is a PLK-1 and Syk inhibitor. | [Biological Activity]
Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of Fc ε RI in rat and human mast cells. Results in the abrogation of degranulation, TNF- α production (IC 50 = 10 μ M) and other related signaling events. |
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