| Identification | Back Directory | [Name]
4H-Pyrrolo[3,4-g]-1,2-benzisoxazole, 5,7-dihydro-7-[(3,4,5-trimethoxyphenyl)methyl]- | [CAS]
2011784-92-0 | [Synonyms]
Tubulin polymerization-IN-37
4H-Pyrrolo[3,4-g]-1,2-benzisoxazole, 5,7-dihydro-7-[(3,4,5-trimethoxyphenyl)methyl]- | [Molecular Formula]
C19H20N2O4 | [MOL File]
2011784-92-0.mol | [Molecular Weight]
340.37 |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1]. | [References]
[1] Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49(3): 1165-81. DOI:10.1021/jm050754u |
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