| Identification | Back Directory | [Name]
1-Formyl-β-carboline | [CAS]
20127-63-3 | [Synonyms]
NSC 149850
Kumujian C
1-Formyl-β-carboline
1-Formyl-beta-carboline
β-Carboline-1-carbaldehyde
9H-b-Carboline-1-carbaldehyde
beta-Carboline-1-carbaldehyde
9H-Beta-carboline-1-carboxaldehyde
9H-pyrido[3,4-b]indole-1-carbaldehyde
9H-Pyrido[3,4-b]indole-1-carboxaldehyde | [Molecular Formula]
C12H8N2O | [MDL Number]
MFCD14706724 | [MOL File]
20127-63-3.mol | [Molecular Weight]
196.205 |
| Chemical Properties | Back Directory | [Occurrence]
A further alkaloid isolated from the heartwood of Picrasma quassinoides. Like the preceding alkaloid it also inhibits the growth of
certain Staphylococcus aureus strains. | [Melting point ]
198-200 °C | [Boiling point ]
440.8±25.0 °C(Predicted) | [density ]
1.392 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
Solid | [pka]
14.21±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1]. | [Synthesis Reference(s)]
Tetrahedron, 50, p. 12329, 1994 DOI: 10.1016/S0040-4020(01)89542-9 | [References]
[1] 1-Formyl- β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes DOI:10.3390/biom11111687 |
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| Company Name: |
BePharm Ltd
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| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
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