| Identification | Back Directory | [Name]
(R)-3,4-DCPG | [CAS]
201730-10-1 | [Synonyms]
(R)-3,4-DCPG
(R)3,4DCPG,(R) 3,4 DCPG
(R)-3,4-DICARBOXYPHENYLGLYCINE
1,2-Benzenedicarboxylic acid, 4-[(R)-aminocarboxymethyl]- | [Molecular Formula]
C10H9NO6 | [MDL Number]
MFCD03453634 | [MOL File]
201730-10-1.mol | [Molecular Weight]
239.18 |
| Chemical Properties | Back Directory | [Boiling point ]
531.0±50.0 °C(Predicted) | [density ]
1.634±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [form ]
Powder | [pka]
1.59±0.10(Predicted) | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
(R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. (R)-3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R)-3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations[1]. | [Biological Activity]
AMPA receptor antagonist with weak activity at NMDA receptors and little activity at kainate receptors. | [storage]
Desiccate at RT | [References]
[1] N K Thomas, et al. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur J Pharmacol. 1997 Nov 5;338(2):111-6. DOI:10.1016/s0014-2999(97)81937-1 |
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