| Chemical Properties | Back Directory | [density ]
1.036±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-20°C | [solubility ]
Water: Soluble | [form ]
A solid | [color ]
White to off-white | [Water Solubility ]
Water: soluble | [SMILES]
[13CH3][13CH2][13C@H]([13CH3])[13C@H](N)[13C](O)=O |
| Hazard Information | Back Directory | [Uses]
L-Isoleucine-13C6 is the 13C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid. | [Biological Activity]
L-Isoleucine-13C6 is intended for use as an internal standard for the quantification of L-isoleucine by GC- or LC-MS. L-Isoleucine is an essential and branched-chain amino acid.1 It is an isomer of L-leucine and a diastereomer of L-alloisoleucine that functions as a nitrogen donor and has roles in glucose consumption, fatty acid metabolism, and immune function.1,2 Urinary levels of L-isoleucine are increased in patients with deficiencies in β-ketothiolase, short/branched-chain specific acyl-CoA dehydrogenase (SBCAD), or 2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD), inborn errors of metabolism characterized by episodic ketoacidosis and neurological impairments.3 | [References]
1.Nie, C., He, T., Zhang, W., et al.Branched chain amino acids: Beyond nutrition metabolismInt. J. Mol. Sci.19(4)954(2018)
2.Zhang, S., Zeng, X., Ren, M., et al.Novel metabolic and physiological functions of branched chain amino acids: A reviewJ. Anim. Sci. Biotechnol.810(2017)
3.Korman, S.H.Inborn errors of isoleucine degradation: A reviewMol. Genet. Metab.89(4)289-299(2006)
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