| Identification | Back Directory | [Name]
10-Debc hydrochloride | [CAS]
201788-90-1 | [Synonyms]
aktX
CCG 206734
CCG-206734
10-Debc hydrochloride
10H-Phenoxazine-10-butanaMine,2-chloro-N,N-diethyl-
4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine
10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazinehydrochloride | [Molecular Formula]
C20H25ClN2O | [MDL Number]
MFCD09038570 | [MOL File]
201788-90-1.mol | [Molecular Weight]
344.88 |
| Chemical Properties | Back Directory | [Melting point ]
>178°C (dec.) | [Boiling point ]
465.1±45.0 °C(Predicted) | [density ]
1.134±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [form ]
White crystalline solid. | [pka]
10.46±0.25(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
10-DEBC Hydrochloride is an AKT inhibitor. Study shows that efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine. | [Biological Activity]
Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μ M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC 50 ~ 2-6 μ M) and induces apoptosis in rhabdomyosarcoma cells. |
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| Company Name: |
Wuhan Topule
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
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