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201809-22-5

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201809-22-5 Structure

201809-22-5 Structure
IdentificationBack Directory
[Name]

4-(5-CARBOXY-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
[CAS]

201809-22-5
[Synonyms]

Boc-piperazine-pyridine-COOH
N4-BOC-6-PIPERAZIN-1-YLNICOTINIC ACID
2-(4-BOC-Piperazino)pyridine-5-carboxylic acid
6-Piperazin-1-ylnicotinic acid, N4-BOC protected
6-(4-Boc-1-piperazinyl)pyridine-3-carboxylic acid
6-(4-Boc-piperazin-1-yl)pyridine-3-carboxylic acid
6-[4-(tert-butoxycarbonyl)piperazino]nicotinic acid
6-Piperazin-1-ylnicotinic acid, N4-BOC protected 97%
6-[4-(PIPERAZIN-1-YL)]NICOTINIC ACID, N4-BOC PROTECTED
6-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]NICOTINIC ACID
6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinicacid97%
6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]nicotinic acid 97%
6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-carboxylic acid
1-(1,1-Dimethylethyl) 4-(5-carboxy-2-pyridinyl)-1-piperazinecarboxylate
4-(5-CARBOXY-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-(5-Carboxy-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester ,97%
1-Piperazinecarboxylicacid, 4-(5-carboxy-2-pyridinyl)-, 1-(1,1-dimethylethyl) ester
[Molecular Formula]

C15H21N3O4
[MDL Number]

MFCD06245543
[MOL File]

201809-22-5.mol
[Molecular Weight]

307.34
Chemical PropertiesBack Directory
[Melting point ]

298 °C
[Boiling point ]

497.4±45.0 °C(Predicted)
[density ]

1.250±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[pka]

3.12±0.10(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
[Risk Statements ]

20/21/22
[Safety Statements ]

24/25-36/37
[Hazard Note ]

Harmful
[HazardClass ]

IRRITANT
[HS Code ]

29335990
Hazard InformationBack Directory
[Chemical Properties]

White solid
[Uses]

Boc-piperazine-pyridine-COOH is a PROTAC Linker that can be used to synthesize PROTAC YW-N-7 (HY-170855)[1].
[References]

[1] Wang Y, et al. Targeting Oncogenic RET Kinase by Simultaneously Inhibiting Kinase Activity and Degrading the Protein. J Med Chem. 2025 Jan 9;68(1):81-94. DOI:10.1021/acs.jmedchem.4c01424
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