| Identification | Back Directory | [Name]
PAMAM DENDRIMER GENERATION 5.5 | [CAS]
202009-67-4 | [Synonyms]
pamam dendrimer, generation 5.5 solution
PAMAM dendrimer, ethylenediamine core, generation 5.5 solution
STARBURST (PAMAM) DENDRIMER, GENERATION 5. 5, 5 WT. % SOLUTION IN METHYL ALCOHOL
PAMAM dendrimer, ethylenediamine core, generation 5.5 solution 5 wt. % in methanol | [MDL Number]
MFCD00197936 | [Molecular Weight]
52900.2 |
| Chemical Properties | Back Directory | [density ]
0.8 g/mL at 25 °C | [refractive index ]
n20/D 1.3378 | [Fp ]
52 °F | [storage temp. ]
2-8°C | [solubility ]
Water: soluble | [form ]
5 wt.% in methanol |
| Hazard Information | Back Directory | [Description]
PAMAM dendrimer G5.5 carboxylate (PAMAM G5.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro.1 It is approximately 103.9 Å in diameter in water and has 192 surface groups.2 Unlike PAMAM dendrimer G3.0 amine (Item No. 39073), PAMAM G5.5 carboxylate (100 µg/ml) does not induce cytotoxicity or autophagy in A549 cells.3 Bimetallic nanoparticles of PAMAM G5.5 carboxylate with gold and platinum scavenge DPPH (Item No. 14805) radicals in a cell-free assay.4 Complexes of PAMAM G5.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 1.48 µM).1WARNING This product is not for human or veterinary use. | [References]
[1] GORDON J. KIRKPATRICK . Evaluation of anionic half generation 3.5–6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin[J]. Journal of Inorganic Biochemistry, 2011, 105 9: Pages 1115-1122. DOI: 10.1016/j.jinorgbio.2011.05.017
[2] GABRIELLA CAMINATI Donald A T Nicholas J Turro. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants[J]. Journal of the American Chemical Society, 1990, 112 23: 8515-8522. DOI: 10.1021/ja00179a041
[3] CHENGGANG LI. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.[J]. Journal of Molecular Cell Biology, 2009, 1 1: 37-45. DOI: 10.1093/jmcb/mjp002
[4] TAKESHI ENDO. Scavenging DPPH radicals catalyzed by binary noble metal–dendrimer nanocomposites[J]. Journal of Colloid and Interface Science, 2006, 302 2: Pages 516-521. DOI: 10.1016/j.jcis.2006.06.053 |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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