2022182-57-4

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2022182-57-4 Structure

Identification	Back Directory
[Name] E3 Ligand-Linker Conjugate 6
[CAS] 2022182-57-4
[Synonyms] E3 Ligand-Linker Conjugate 6 Acetamide, N-(3-aminopropyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
[Molecular Formula] C18H20N4O6
[MDL Number] MFCD31812749
[MOL File] 2022182-57-4.mol
[Molecular Weight] 388.37

Hazard Information	Back Directory
[Uses] Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
[IC 50] Cereblon
[References] [1] Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262. DOI:10.1016/j.bmcl.2016.09.048

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