| Identification | Back Directory | [Name]
Phosphoramidous acid, bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(methylamino)-2-[(methylamino)carbonyl]-3-oxopropyl 2-cyanoethyl ester (9CI) | [CAS]
202284-84-2 | [Synonyms]
Phosphorylation amidite
Chemical phosphorylation amidite
Solid Chemical phosphorylation reagent II
3-(4,4'-Dimethoxytrityloxy)-2,2-dicarboxymethylamido]propyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite
Phosphoramidous acid, bis(1-methylethyl)-, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(methylamino)-2-[(methylamino)carbonyl]-3-oxopropyl 2-cyanoethyl ester (9CI) | [Molecular Formula]
C37H49N4O7P | [MOL File]
202284-84-2.mol | [Molecular Weight]
692.78 |
| Chemical Properties | Back Directory | [Boiling point ]
802.6±65.0 °C(Predicted) | [pka]
13.05±0.46(Predicted) | [InChIKey]
HAUCJKGKHJPPNN-UHFFFAOYSA-N | [SMILES]
P(N(C(C)C)C(C)C)(OCCC#N)OCC(COC(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)(C(NC)=O)C(NC)=O |
| Hazard Information | Back Directory | [Description]
Phosphorylation amidite is a reagent for the synthesis of oligonucleotides possessing 5'-terminal phosphate residues. | [Uses]
Chemical phosphorylation amidite is a click chemical class ADC linker. Click chemistry has good biological orthogonality characteristics: biocompatible, fast and highly specific in the biological environment, and has great application potential in the binding between nucleic acids, lipids, proteins and other molecules[1]. | [References]
[1] Zhang X, et al. Applications of azide-based bioorthogonal click chemistry in glycobiology. Molecules. 2013 Jun 19;18(6):7145-59. DOI:10.3390/molecules18067145 |
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