| Identification | Back Directory | [Name]
Lin28-IN-1 | [CAS]
2024548-03-4 | [Synonyms]
Lin28-IN-1
Lin28-let-7a antagonist 1
1-Piperazinecarboxylic acid, 4-[1-(4-carboxyphenyl)-1,4-dihydro-4,4-dimethyl-8-nitro[1]benzopyrano[4,3-c]pyrazol-7-yl]-, 1-(phenylmethyl) ester | [Molecular Formula]
C31H29N5O7 | [MDL Number]
MFCD30741839 | [MOL File]
2024548-03-4.mol | [Molecular Weight]
583.59 |
| Chemical Properties | Back Directory | [Boiling point ]
813.8±65.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.72±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction. | [References]
[1] Lim D, et al. Discovery of a Small-Molecule Inhibitor of Protein-MicroRNA Interaction Using Binding Assay with a Site-Specifically Labeled Lin28. J Am Chem Soc. 2016 Oct 7. DOI:10.1021/jacs.6b06965 |
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