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Prexigebersen is an antisense oligonucleotide designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2). | [References]
[1] Maro Ohanian, Tara L. Lin, Ellen Ritchie, et al. Pierce, Ana Tari Ashizawa, Hagop Kantarjian, Jorge E. Cortes, Gail J. Roboz; Safety and Efficacy of Lower Intensity Induction Therapy with Intravenous Prexigebersen (BP1001) in Patients with High-Risk and Relapsed/Refractory Acute Myeloid Leukemia (AML).?Blood?2021; 138 (Supplement 1): 1281.
[2] Tremblay G, Khalafaghian G, Legault J, Nielsen P, Bartlett A. Dual ligation hybridization assay for the specific determination of oligonucleotide therapeutics. Bioanalysis. 2011;3(5):499-508. DOI:10.4155/bio.11.18 |
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