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2028288-77-7

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2028288-77-7 Structure

2028288-77-7 Structure
IdentificationBack Directory
[Name]

TCO-PEG3-Amine
[CAS]

2028288-77-7
[Synonyms]

TCO-PEG3-Amine
TCO-C3-PEG3-C3-amine
(4E)-TCO-C3-PEG3-C3-amine
[Molecular Formula]

C19H36N2O5
[MDL Number]

MFCD30458038
[MOL File]

2028288-77-7.mol
[Molecular Weight]

372.51
Chemical PropertiesBack Directory
[Boiling point ]

506.5±50.0 °C(Predicted)
[density ]

1.06±0.1 g/cm3(Predicted)
[pka]

12.38±0.46(Predicted)
Hazard InformationBack Directory
[Description]

TCO-PEG3-amine is a click chemistry crosslinking reagent. It can be used to derivatize NHS activated esters through a stable amide bond or carboxyl groups in the presence of of activators (e.g. EDC, or HATU). TCO enable click chemistry with tetrazine. PEG spacer improves water solubility.
[Uses]

TCO-C3-PEG3-C3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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