| Identification | Back Directory | [Name]
L-Glutamic acid, N-[4-[[3-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]amino]benzoyl]- | [CAS]
2028296-64-0 | [Synonyms]
FRα-IN-1
L-Glutamic acid, N-[4-[[3-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]amino]benzoyl]- | [Molecular Formula]
C21H24N6O6 | [MOL File]
2028296-64-0.mol | [Molecular Weight]
456.45 |
| Hazard Information | Back Directory | [Uses]
FRα-IN-1 (Compound 4) is a tumor-targeting agent. FRα-IN-1 shows selective anticancer activity towards folate receptors (FRα and FRβ) expression cells[1]. | [References]
[1] Golani LK, et al. Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorg Med Chem. 2020 Jun 15;28( DOI:10.1016/j.bmc.2020.115544 |
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