| Identification | Back Directory | [Name]
1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate | [CAS]
2030410-25-2 | [Synonyms]
PF 04449913 maleate
1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
1-((2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate salt | [Molecular Formula]
C25H26N6O5 | [MDL Number]
MFCD29037212 | [MOL File]
2030410-25-2.mol | [Molecular Weight]
490.52 |
| Hazard Information | Back Directory | [Uses]
Glasdegib maleate (PF-04449913 maleate) is a potent and orally bioavailable smoothened inhibitor. Glasdegib maleate binds to human SMO (amino acids 181-787) with IC50value of 4 nM[1]. | [storage]
Store at -20°C | [References]
[1] Sadarangani A, et al. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21;13:98. DOI:10.1186/s12967-015-0453-9 |
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