| Identification | Back Directory | [Name]
2-amino-6-methylpyridin-3-ol | [CAS]
20348-16-7 | [Synonyms]
Einecs 243-752-7
2-amino-6-methylpyridin-3-ol
2-Amino-3-Hydroxy-6-Picoline
3-Pyridinol, 2-amino-6-methyl-
2-Amino-3-hydroxy-6-methylpyridine
2-amino-6-methylpyridin-3-ol ISO 9001：2015 REACH
N1,N4-bis(2-chloroethyl)cyclohexane-1,4-dicarboxamide | [EINECS(EC#)]
243-752-7 | [Molecular Formula]
C6H8N2O | [MDL Number]
MFCD09839245 | [MOL File]
20348-16-7.mol | [Molecular Weight]
124.14 |
| Chemical Properties | Back Directory | [Melting point ]
153-154.5 °C | [Boiling point ]
342.7±42.0 °C(Predicted) | [density ]
1.245±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
5.46±0.23(Predicted) | [Appearance]
Yellow to brown Solid | [InChI]
InChI=1S/C6H8N2O/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3,(H2,7,8) | [InChIKey]
WJRVHFJZHFWCMS-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(C)=CC=C1O |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-3-hydroxy-6-methylpyridine from 3-hydroxy-6-methyl-2-nitropyridine: 3-hydroxy-6-methyl-2-nitropyridine (30 g, 194.6 mmol) was dissolved in ethanol and the hydrogenation reaction was carried out for 1 hr at 50 °C using hydrogen (5 psi) and 20% Pd(OH)2/C catalyst. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford the target product 2-amino-3-hydroxy-6-methylpyridine as a brown solid (23.68 g, 98% yield). The NMR data of the product was consistent with the expected structure. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2679 - 2684
[2] Patent: US2002/169200, 2002, A1
[3] Patent: US2004/92538, 2004, A1. Location in patent: Page 41-42
[4] Patent: WO2006/51410, 2006, A1. Location in patent: Page/Page column 40
[5] Patent: WO2008/51533, 2008, A2. Location in patent: Page/Page column 81-82 |
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