| Identification | Back Directory | [Name]
METHAZOLE | [CAS]
20354-26-1 | [Synonyms]
Probe
Tunic
VC 438
vcs438
Paxilon
Bioxone
Metazol
Mezopur
VCS 438
probe75
Probe 75
Oxydiazol
METHAZOLE
Probe 75 WP
Chlormethazole
Methazole Standard
methazole (bsi, ansi,australia,wssa)
2-(3,4-dichlorophenyl)-4-methyl-1,2,4-oxadiazolidinedione
2-(3,4-DICHLOROPHENYL)-4-METHYL-1,2,4-OXADIAZOLIDINE-3,5-D.
4-oxadiazolidine-3,5-dione,2-(3,4-dichlorophenyl)-4-methyl-2
2-(3,4-DICHLOROPHENYL)-4-METHYL-1,2,4-OXADIAZOLIDINE-3,5-DIONE
1,2,4-Oxadiazolidine-3,5-dione, 2-(3,4-dichlorophenyl)-4-methyl-
2-(3,4-dichlorophenyl)-4-methyl-1,2,4-oxadiazolidinedione methazole | [EINECS(EC#)]
243-761-6 | [Molecular Formula]
C9H6Cl2N2O3 | [MDL Number]
MFCD00055336 | [MOL File]
20354-26-1.mol | [Molecular Weight]
261.06 |
| Chemical Properties | Back Directory | [Melting point ]
123-124° | [Boiling point ]
348.7±52.0 °C(Predicted) | [density ]
1.2400 | [refractive index ]
1.6100 (estimate) | [storage temp. ]
0-6°C | [pka]
-2.16±0.20(Predicted) | [color ]
Light-tan solid | [Water Solubility ]
1.5mg/L(25 ºC) | [Henry's Law Constant]
4.3×101 mol/(m3Pa) at 25℃, HSDB (2015) | [EPA Substance Registry System]
Methazole (20354-26-1) |
| Hazard Information | Back Directory | [Uses]
Herbicide. | [Uses]
Methazole is an herbicide used on fungus in the protection of crops.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list. | [Definition]
ChEBI: Methazole is a dichlorobenzene. | [Production Methods]
The industrial synthesis of methazole typically begins with the construction of a 1,3,4-oxadiazole ring, a five-membered heterocycle containing nitrogen and oxygen atoms. This ring is formed via cyclisation reactions involving hydrazides and carboxylic acid derivatives under dehydrating conditions. Once the oxadiazole core is established, it is coupled with a chlorinated phenyl group, often through nucleophilic aromatic substitution or Friedel–Crafts-type reactions, to yield the herbicidal structure. The synthesis is carried out in organic solvents like acetonitrile or dichloromethane, with temperature and pH carefully controlled to ensure high yield and purity. | [General Description]
Colorless crystals to light tan solid. Non corrosive. Herbicide. | [Air & Water Reactions]
Hydrolyzed by strong acids and bases. | [Reactivity Profile]
MEETHAZOLE is an oxadiazole. | [Mechanism of action]
Selective. Methazole demonstrates selective phytotoxic activity through inhibition of photosynthetic electron transport which induces stunting and chlorosis | [Safety Profile]
Moderately toxic by ingestion.When heated to decomposition it emits very toxic fumesof Cl-and NOx. | [Pesticide Type]
Herbicide |
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