| Identification | Back Directory | [Name]
PLX3397 HCl | [CAS]
2040295-03-0 | [Synonyms]
PLX3397 HCl
Pexidartinib hcl
Pexidartinib Hydrochloride Salt
Pexidartinib hydrochloride (PLX-3397) | [Molecular Formula]
C20H16Cl2F3N5 | [MDL Number]
MFCD30738678 | [MOL File]
2040295-03-0.mol | [Molecular Weight]
454.28 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:60.0(Max Conc. mg/mL);132.1(Max Conc. mM) | [form ]
Solid | [color ]
White to off-white | [InChIKey]
CJLUYLRKLUYCEK-UHFFFAOYSA-N | [SMILES]
C(C1=CN=C(NCC2=CN=C(C(F)(F)F)C=C2)C=C1)C1=CNC2=NC=C(Cl)C=C12.Cl |
| Hazard Information | Back Directory | [Uses]
Pexidartinib Hydrochloride is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition. | [in vivo]
Pexidartinib can be used to deplete the microglia cells in mice.
Pexidartinib (290 ppm in AIN-76A standard chow, 21 days) depletes the microglia cells in brain by 70% in adult male C57BL/6?J mice (20–25?g)[5].
Pexidartinib (600 ppm in chow, 10 days and 30 days ) depletes the microglia cells more than 90% in brain of C57BL/6J mice[6].
Pexidartinib hydrochloride (0.25, 1 mg/kg, i.p., twice daily for 8 days) inhibits the proliferation of microglia and BrdU-positive cells in neonatal mice[2].
Pexidartinib hydrochloride (1 mg/kg, twice daily for 8 day) shows no obvious effect on the cleaved caspase-3-positive cells in mice[2].
Pexidartinib hydrochloride (50 mg/kg; p.o.; every second day for 3 weeks) reduces tissue macrophage levels without affecting glucose homeostasis in mice[4]. | Animal Model: | Neonatal mice[2] | | Dosage: | 0.25, 1 mg/kg | | Administration: | I.P. twice daily for 8 days | | Result: | Decreased the number of microglia and BrdU-positive proliferative cells, but did not change the cleaved caspase-3-positive cells. |
| Animal Model: | 10-week old litter mate C57BL/6 mice (chow and high-fat diet fed mice)[4] | | Dosage: | 50?mg/kg | | Administration: | P.o.; every second day for 3 weeks | | Result: | Substantially reduced macrophage numbers in adipose tissue of both chow and high-fat diet fed mice without affecting total myeloid cell levels.
|
| [storage]
Store at -20°C |
|
| Company Name: |
Twochem Co.Ltd.
|
| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
|