| Identification | Back Directory | [Name]
MMP-9/MMP-13 INHIBITOR I | [CAS]
204140-01-2 | [Synonyms]
MMP-9/MMP-13 INHIBITOR I
MMP-9/MMP-13 INHIBITOR II
N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYLPIPERAZINE-2-CARBOXAMIDE
N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-(4-BIPHENYLCARBONYL)PIPERAZINE-2-CARBOXAMIDE
2-Piperazinecarboxamide, 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]- | [Molecular Formula]
C25H25N3O6S | [MDL Number]
MFCD03453559 | [MOL File]
204140-01-2.mol | [Molecular Weight]
495.55 |
| Chemical Properties | Back Directory | [density ]
1.364±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO or methanol | [form ]
Solid | [pka]
9.38±0.23(Predicted) | [color ]
White to off-white | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Description]
MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum. | [Uses]
A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13 | [IC 50]
MMP-9: 0.9 nM (IC50); MMP-13: 0.9 nM (IC50); MMP-1: 43 nM (IC50); MMP-3: 23 nM (IC50); MMP-7: 931 nM (IC50) | [References]
[1] MENYAN CHENG. Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors[J]. Journal of Medicinal Chemistry, 2000, 43 3: 369-380. DOI: 10.1021/jm990366q
[2] MAURO PRATO. Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-alpha production in human monocytes: role of matrix metalloproteinases in the pathogenesis of falciparum malaria.[J]. Journal of immunology, 2005, 175 10: 6436-6442. DOI: 10.4049/jimmunol.175.10.6436
[3] PETER STORZ. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.[J]. Molecular and Cellular Biology, 2009, 29 18: 4906-4917. DOI: 10.1128/mcb.00077-09
[4] MUTHULEKHA SWAMYDAS. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases.[J]. Cell Adhesion & Migration, 2013, 7 3: 315-324. DOI: 10.4161/cam.25138 |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|