| Identification | Back Directory | [Name]
Propanoic acid, 3-(2-propen-1-yldithio)-, 3-[[4-[(3-bromophenyl)amino]-6-methoxy-7-quinazolinyl]oxy]propyl ester | [CAS]
2044508-48-5 | [Synonyms]
EGFR-IN-50
Propanoic acid, 3-(2-propen-1-yldithio)-, 3-[[4-[(3-bromophenyl)amino]-6-methoxy-7-quinazolinyl]oxy]propyl ester | [Molecular Formula]
C24H26BrN3O4S2 | [MOL File]
2044508-48-5.mol | [Molecular Weight]
564.51 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-50 (Compound 9h) is a potent EGFR inhibitor against L858R resistance mutation (TEL-EGFR-L858R-BaF3: GI50=8 nM, TEL-EGFR-T790M-L858R-BaF3: GI50=6.03 μM). EGFR-IN-50 shows anti-proliferative activity to cancer cells[1]. | [References]
[1] You-Guang Zheng, et al. Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H2S) donors as potent EGFR inhibitors against L858R resistance mutation. Eur J Med Chem. 2020 Sep 15;202:112522. DOI:10.1016/j.ejmech.2020.112522 |
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