| Identification | Back Directory | [Name]
N-[2-(tert-ButyldiMethylsilyloxy)ethyl]MethylaMine | [CAS]
204580-28-9 | [Synonyms]
N-[2-(tert-ButyldiMethylsilyloxy)ethyl]MethylaMine
[2-[(tert-Butyldimethylsilyl)oxy]ethyl]methylamine
[2-(tert-Butyldimethylsilanyloxy)ethyl]methylamine
2-[(tert-Butyldimethylsilyl)oxy]-N-methylethanamine
N-[2-(tert-Butyldimethylsilyloxy)ethyl]-N-methylamine
Ethanamine, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-N-methyl- | [Molecular Formula]
C9H23NOSi | [MDL Number]
MFCD20662141 | [MOL File]
204580-28-9.mol | [Molecular Weight]
189.37 |
| Chemical Properties | Back Directory | [Boiling point ]
193.8±23.0 °C(Predicted) | [density ]
0.830±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
9.55±0.10(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: To a stirred solution of N-methyl-2-hydroxyethylamine (10 g, 133.13 mmol) in dichloromethane (200 mL) was added diisopropylethylamine (30.8 mL, 186.39 mmol) and tert-butyldimethylchlorosilane (20.06 g, 133.13 mmol) sequentially at room temperature. The reaction mixture was stirred for 16 hours. After the reaction was completed, water was added and the mixture was extracted with dichloromethane. The organic phase was separated, washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give N-[2-(tert-butyldimethylsilyloxy)ethyl]methylamine (18 g, 71.39%) as a yellow liquid. | [References]
[1] Organic and Biomolecular Chemistry, 2009, vol. 7, # 4, p. 655 - 659
[2] Patent: US2014/194431, 2014, A1. Location in patent: Paragraph 0160-0161
[3] Organic Letters, 2016, vol. 18, # 15, p. 3878 - 3881
[4] Patent: WO2015/57938, 2015, A1. Location in patent: Page/Page column 119-120
[5] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 2, p. 328 - 333 |
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