| Identification | Back Directory | [Name]
2-Naphthalenamine, 5-(2-fluorophenyl)-1,2,3,4-tetrahydro-N,N-dimethyl-, (2S)- | [CAS]
2048491-06-9 | [Synonyms]
FPT
2-Naphthalenamine, 5-(2-fluorophenyl)-1,2,3,4-tetrahydro-N,N-dimethyl-, (2S)- | [Molecular Formula]
C18H20FN | [MOL File]
2048491-06-9.mol | [Molecular Weight]
269.36 |
| Chemical Properties | Back Directory | [Boiling point ]
395.3±42.0 °C(predicted) | [density ]
1.11±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Liquid
(Density: 1.119±0.10 g/cm3) | [pka]
9.17±0.20(predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT1AR, a full agonist at 5-HT1BR and 5-HT1DR with EC50s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT7R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models[1]. | [IC 50]
5-HT1A Receptor: 39.3 nM (IC50); 5-HT1B Receptor: 1.2 nM (IC50); 5-HT1D Receptor: 0.5 nM (IC50); 5-HT1A Receptor: 4.3 nM (Ki); 5-HT1B Receptor: 2.3 nM (Ki); 5-HT1D Receptor: 1.2 nM (Ki); 5-HT1F Receptor: >10,000 nM (Ki); 5-HT7 Receptor | [References]
[1] Tanishka S Saraf, et al. FPT, a 2-Aminotetralin, Is a Potent Serotonin 5-HT1A, 5-HT1B, and 5-HT1D Receptor Agonist That Modulates Cortical Electroencephalogram Activity in Adult Fmr1 Knockout Mice. ACS Chem Neurosci. 2022 Dec 21;13(24):3629-3640. DOI:10.1021/acschemneuro.2c00574 |
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