| Identification | Back Directory | [Name]
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE | [CAS]
205242-62-2 | [Synonyms]
NAS-181
NAS-181 methanesulfonate
(2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE | [Molecular Formula]
C20H30N2O7S | [MDL Number]
MFCD06798366 | [MOL File]
205242-62-2.mol | [Molecular Weight]
442.53 |
| Hazard Information | Back Directory | [Uses]
NAS-181 is a SR-1B antagonist. | [Biological Activity]
Potent, selective antagonist at the rat 5-HT 1B receptor (K i = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo . | [in vivo]
NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1]. | Animal Model: | Rats[1] | | Dosage: | 20 mg/kg | | Administration: | S.c. | | Result: | Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal?cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40?60%). |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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