205252-59-1

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205252-59-1 Structure

Identification	Back Directory
[Name] UAB 30
[CAS] 205252-59-1
[Synonyms] UAB 30 (all-E)-UAB30 2,4,6-Octatrienoic acid, 8-(3,4-dihydro-1(2H)-naphthalenylidene)-3,7-dimethyl-, (2E,4E,6E,8E)-
[Molecular Formula] C20H22O2
[MDL Number] MFCD11840706
[MOL File] 205252-59-1.mol
[Molecular Weight] 294.39

Hazard Information	Back Directory
[Uses] (all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively[1][2].
[References] [1] Adele P. Williams, et al. UAB30, A Novel Rexinoid Agonist, Decreases Stemness In Group 3 Medulloblastoma Human Cell Line Xenografts. Transl Oncol. 2019 Oct;12(10):1364-1374. [2] Chu-Fang Chou, et al. The Retinoid X Receptor Agonist, 9-cis UAB30, Inhibits Cutaneous T-cell Lymphoma Proliferation Through the SKP2-p27kip1 Axis. J Dermatol Sci. 2018 Jun; 90(3): 343–356.

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