| Identification | Back Directory | [Name]
1-Piperazinecarboxamide, 4-(6,7-dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)- | [CAS]
205255-11-4 | [Synonyms]
KN 1022
1-Piperazinecarboxamide, 4-(6,7-dimethoxy-4-quinazolinyl)-N-(4-nitrophenyl)- | [Molecular Formula]
C21H22N6O5 | [MOL File]
205255-11-4.mol | [Molecular Weight]
438.44 |
| Chemical Properties | Back Directory | [Melting point ]
272-274 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [Boiling point ]
711.1±60.0 °C(Predicted) | [density ]
1.406±0.06 g/cm3(Predicted) | [pka]
12.73±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
KN1022 an inhibitor of phosphorylation of platelet-derived growth factor receptor (PDGFR) with IC50 of 0.24 μM[1]. | [References]
[1] Kenji Matsuno, et al. Potent and selective inhibitors of platelet-derived growth factor receptor phosphorylation. 1. Synthesis, structure-activity relationship, and biological effects of a new class of quinazoline derivatives. J Med Chem. 2002 Jul 4;45(14):3057-66. DOI:10.1021/jm010428o |
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InvivoChem
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13549236410 |
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https://www.invivochem.cn/ |
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