| Identification | Back Directory | [Name]
Acid-PEG4-S-S-PEG4-Acid | [CAS]
2055015-40-0 | [Synonyms]
Acid-PEG4-S-S-PEG4-Acid
4,7,10,13,20,23,26,29-Octaoxa-16,17-dithiadotriacontanedioic acid | [Molecular Formula]
C22H42O12S2 | [MDL Number]
MFCD28950762 | [MOL File]
2055015-40-0.mol | [Molecular Weight]
562.69 |
| Chemical Properties | Back Directory | [Boiling point ]
683.6±55.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [form ]
Liquid | [pka]
3.97±0.10(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Description]
Acid-PEG4-SS-PEG4-acid is a homobifunctional cleavable linker with carboxylic acid groups at both sides. The terminal carboxylic acids can be reacted with primary amines in the presences of activators such as EDC and HATU to form stable amide bonds. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. | [Uses]
Acid-PEG4-S-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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