| Identification | Back Directory | [Name]
Mal-PEG2-Val-Cit-amido-PAB-OH | [CAS]
2055041-38-6 | [Synonyms]
Mal-PEG2-Val-Cit-PAB-OH
Mal-PEG2-Val-Cit-amido-PAB-OH | [Molecular Formula]
C29H42N6O9 | [MDL Number]
MFCD29918233 | [MOL File]
2055041-38-6.mol | [Molecular Weight]
618.68 |
| Chemical Properties | Back Directory | [Boiling point ]
948.4±65.0 °C(Predicted) | [density ]
1.294±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DMF | [form ]
Solid | [pka]
13.41±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. PEG chain increases the water solubility of the compound. | [Uses]
Mal-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG2-Val-Cit-PAB-OH also can be used as a PROTAC linker that can be used in the synthesis of PROTACs. | [IC 50]
Cleavable Linker; Protease Cleavable Linker; PEGs |
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| Company Name: |
Abydos Scientific
|
| Telephone: |
18936879710 18851749494 |
| Website: |
www.abydoscientific.com/index.html |
| Company Name: |
csynbio
|
| Telephone: |
15051477682 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList1949820/0_EN.htm |
| Company Name: |
YantaiBio
|
| Telephone: |
13758194781; 13758194781 |
| Website: |
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