| Identification | Back Directory | [Name]
Mal-PEG4-Val-Cit-PAB-OH | [CAS]
2055041-39-7 | [Synonyms]
Mal-PEG4-Val-Cit-PAB-OH
L-Ornithinamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxo-4,7,10,13-tetraoxapentadec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- | [Molecular Formula]
C33H50N6O11 | [MOL File]
2055041-39-7.mol | [Molecular Weight]
706.78 |
| Chemical Properties | Back Directory | [Boiling point ]
973.9±65.0 °C(Predicted) | [density ]
1.269±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Solid | [pka]
13.41±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
Mal-PEG4-Val-Cit-PAB-OH is a cleavable peptide linker. The Val-Cit was designed to be cleaved by Cathepsin B. The maleimide group is reactive toward thiol groups between pH 6.5 to 7.5. PEG4 arm increases the aqueous solubility of the compound. | [Uses]
Mal-PEG4-Val-Cit-PAB-OH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [IC 50]
Protease Cleavable Linker; Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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Abydos Scientific
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025-84767922 18936879710 |
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http://www.abydoscientific.com/index.html |
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csynbio
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15051477682 |
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www.chemicalbook.com/ShowSupplierProductsList1949820/0_EN.htm |
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