| Identification | Back Directory | [Name]
NH-(PEG4-t-butyl ester)2 | [CAS]
2055041-41-1 | [Synonyms]
HN-(PEG4-CH2CH2COOtBu)2
NH-(PEG4-t-butyl ester)2
NH-bis(PEG4-t-butyl ester)
4,7,10,13,19,22,25,28-Octaoxa-16-azahentriacontanedioic acid, 1,31-bis(1,1-dimethylethyl) ester | [Molecular Formula]
C30H59NO12 | [MDL Number]
MFCD29912666 | [MOL File]
2055041-41-1.mol | [Molecular Weight]
625.79 |
| Chemical Properties | Back Directory | [Boiling point ]
625.8±50.0 °C(Predicted) | [density ]
1.059±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
8.39±0.19(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
NH-bis(PEG4-t-butyl ester) is a very useful PEG reagent containing an amino group with two t-butyl esters. The amino groups is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
NH-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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