| Identification | Back Directory | [Name]
N-(Boc-PEG3)-N-Bis-(PEG2-alcohol) | [CAS]
2055042-60-7 | [Synonyms]
N-(Boc-PEG3)-N-Bis-(PEG2-alcohol)
5,8,11,17,20-Pentaoxa-2,14-diazadocosanoic acid, 22-hydroxy-14-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C25H52N2O11 | [MDL Number]
MFCD30182039 | [MOL File]
2055042-60-7.mol | [Molecular Weight]
556.69 |
| Chemical Properties | Back Directory | [Boiling point ]
638.8±55.0 °C(Predicted) | [density ]
1.112±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [pka]
12.23±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a branched PEG linker with a Boc protecting group and two PEG2-alcohol branches connected to a central nitrogen. The Boc can be removed under acidic conditions. The hydroxyl groups can react the further derivatize the compound. The hydrophilic PEG linkers increase the water solubility of the compound. Branched PEG linkers have increased conjugation efficiency. | [Uses]
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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