| Identification | Back Directory | [Name]
SR12460 | [CAS]
2055101-66-9 | [Synonyms]
SR12460
Acetamide, N-(5-chloro-2-pyridinyl)-2-[[2-(3,5-difluorophenyl)ethyl]amino]- | [Molecular Formula]
C15H14ClF2N3O | [MOL File]
2055101-66-9.mol | [Molecular Weight]
325.74 |
| Chemical Properties | Back Directory | [Boiling point ]
486.5±45.0 °C(Predicted) | [density ]
1.364±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 15 mg/ml | [form ]
A crystalline solid | [pka]
12.09±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1 It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 µM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in the mdx mouse model of Duchenne muscular dystrophy.WARNING This product is not for human or veterinary use. | [storage]
Store at -20°C |
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| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
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