| Identification | Back Directory | [Name]
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)phenyl]amino]-5-chloro-4-pyrimidinyl]amino]phenyl]-2-chloro- | [CAS]
2057423-46-6 | [Synonyms]
EGFR-IN-55
2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)phenyl]amino]-5-chloro-4-pyrimidinyl]amino]phenyl]-2-chloro- | [Molecular Formula]
C25H25Cl2N7O2 | [MOL File]
2057423-46-6.mol | [Molecular Weight]
526.42 |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1]. | [IC 50]
EGFRL858R/T790M: 3.9 nM (IC50); EGFRWT: 70 nM (IC50) | [References]
[1] Shao J, et al. Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg Med Chem. 2020 Oct 1;28(19):115680. DOI:10.1016/j.bmc.2020.115680 |
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