| Identification | Back Directory | [Name]
STAT3-IN-1 | [CAS]
2059952-75-7 | [Synonyms]
STAT3-IN-1
2-Propenamide, N-[4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)- | [Molecular Formula]
C28H29NO6 | [MDL Number]
MFCD32174234 | [MOL File]
2059952-75-7.mol | [Molecular Weight]
475.53 |
| Chemical Properties | Back Directory | [Boiling point ]
689.3±55.0 °C(Predicted) | [density ]
1.205±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: 125 mg/mL (262.86 mM) | [form ]
Solid | [pka]
12.63±0.70(Predicted) | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-1 is a STAT3 inhibitor. Antitumor activity. | [in vivo]
STAT3-IN-1 (compound 7d: 10, 20 mg/kg, two weeks) arrests tumor growth with low toxicity in mouse-xenograft model[1]. | Animal Model: | Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells[1]. | | Dosage: | 10, 20 mg/kg. | | Administration: | Oral administration once every other day for two weeks. | | Result: | Arrested tumor growth with no obvious body weight loss. |
| [IC 50]
Stat-3: 1.82 μM (IC50, in HT29 cells); Stat-3: 2.14 μM (IC50, in MDA-MB 231 cells) | [storage]
Store at -20°C |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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