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2059952-75-7

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2059952-75-7 Structure

2059952-75-7 Structure
IdentificationBack Directory
[Name]

STAT3-IN-1
[CAS]

2059952-75-7
[Synonyms]

STAT3-IN-1
2-Propenamide, N-[4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl]phenyl]-3-(3,4,5-trimethoxyphenyl)-, (2E)-
[Molecular Formula]

C28H29NO6
[MDL Number]

MFCD32174234
[MOL File]

2059952-75-7.mol
[Molecular Weight]

475.53
Chemical PropertiesBack Directory
[Boiling point ]

689.3±55.0 °C(Predicted)
[density ]

1.205±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

DMSO: 125 mg/mL (262.86 mM)
[form ]

Solid
[pka]

12.63±0.70(Predicted)
[color ]

Light yellow to orange
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

STAT3-IN-1 is a STAT3 inhibitor. Antitumor activity.
[in vivo]

STAT3-IN-1 (compound 7d: 10, 20 mg/kg, two weeks) arrests tumor growth with low toxicity in mouse-xenograft model[1].

Animal Model:Mouse-xenograft model bearing inoculation of mice breast cancer 4T1 cells[1].
Dosage:10, 20 mg/kg.
Administration:Oral administration once every other day for two weeks.
Result: Arrested tumor growth with no obvious body weight loss.
[IC 50]

Stat-3: 1.82 μM (IC50, in HT29 cells); Stat-3: 2.14 μM (IC50, in MDA-MB 231 cells)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

STAT3-IN-1(2059952-75-7)1HNMR
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