| Identification | Back Directory | [Name]
MS-PPOH | [CAS]
206052-02-0 | [Synonyms]
MS-PPOH
MS PPOH,MSPPOH
N-methylsulfonyl-6-(2-prop-2-ynoxyphenyl)hexanamide
Benzenehexanamide, N-(methylsulfonyl)-2-(2-propyn-1-yloxy)- | [Molecular Formula]
C16H21NO4S | [MDL Number]
MFCD03412029 | [MOL File]
206052-02-0.mol | [Molecular Weight]
323.41 |
| Chemical Properties | Back Directory | [density ]
1.186±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2)(1:2): .30 mg/ml; Ethanol: 25 mg/ml | [form ]
A crystalline solid | [pka]
4.68±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes. | [in vivo]
MS-PPOH (20 mg/kg/day, i.v.) for 6 days significantly reduced renal levels of epoxyeicosatrienoic acids (EETs) in Dahl salt-resistant rats on 2% NaCl drinking solution[3]. | Animal Model: | Six-week-old male stroke-prone spontaneously hypertensive rats (SHRSP)[3] | | Dosage: | 20 mg/kg/day | | Administration: | Intravenously | | Result: | Treatment had negligible effects on systolic blood pressure (SBP) in saline-drinking SHRSP after 1 week, 160 vs. 167 mmHg, or 2 weeks of treatment, 171 vs. 175 mmHg, for vehicle vs. MS-PPOH, respectively. |
| [IC 50]
CYP2 | [storage]
Store at -20°C |
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