| Identification | Back Directory | [Name]
t-Boc-N-Amido-PEG5-propargyl | [CAS]
2062663-67-4 | [Synonyms]
BocNH-P5-Propargyl
Propargyl-PEG5-NHBoc
Boc-NH-PEG5-propargyl
t-Boc-N-Amido-PEG5-propargyl
5,8,11,14,17-Pentaoxa-2-azaeicos-19-ynoic acid, 1,1-dimethylethyl ester | [Molecular Formula]
C18H33NO7 | [MDL Number]
MFCD30534431 | [MOL File]
2062663-67-4.mol | [Molecular Weight]
375.46 |
| Hazard Information | Back Directory | [Description]
t-Boc-N-Amido-PEG5-propargyl comprises a propargyl group and Boc-protected amine. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
Boc-NH-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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