| Identification | Back Directory | [Name]
L-R4W2 | [CAS]
206350-79-0 | [Synonyms]
L-R4W2
L-Tryptophanamide, L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-tryptophyl- (9CI) | [Molecular Formula]
C46H71N21O6 | [MDL Number]
MFCD03791319 | [MOL File]
206350-79-0.mol | [Molecular Weight]
1014.19 |
| Chemical Properties | Back Directory | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [form ]
Powder | [pka]
13.31±0.46(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Arg-Arg-Arg-Arg-Trp-Trp-NH2 |
| Hazard Information | Back Directory | [Uses]
L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 may act as a potent analgesic[1][2]. | [IC 50]
TRPV1: 0.1 μM (IC50) | [References]
[1] Planells-Cases R, et, al. Arginine-rich peptides are blockers of VR-1 channels with analgesic activity. FEBS Lett. 2000 Sep 15; 481(2): 131-6. DOI:10.1016/s0014-5793(00)01982-7
[2] Himmel HM, et, al. The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 2002 Jun; 301(3): 981-6. DOI:10.1124/jpet.301.3.981 |
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