| Identification | Back Directory | [Synonyms]
CGP78608HCl
CGP 78608 hydrochlor
CGP 78608 HYDROCHLORIDE
Phosphonic acid, P-[(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]-
((1S)-1-(((7-Bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl)amino)ethyl]phosphonicacidhydrochloride
[(1S)-1-[[(7-BROMO-1,2,3,4-TETRAHYDRO-2,3-DIOXO-5-QUINOXALINYL)METHYL]AMINO]ETHYL]PHOSPHONIC ACID HYDROCHLORIDE | [Molecular Weight]
378.12 |
| Hazard Information | Back Directory | [Uses]
CGP 78608 is a potent and selective NMDA antagonist. | [Definition]
ChEBI: CGP 78608 is a phosphonic acid in which the hydrogen attached to phosphorous is substituted by a 1-{[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)methyl]amino}ethyl group. Potent and selective NMDA antagonist that acts through the glycine site (IC50 = 5 nM). Displays >500-fold selectivity over kainate and AMPA receptors (IC50 values are 2.7 and 3 muM respectively). Anticonvulsant in vivo following systemic administration. It has a role as a NMDA receptor antagonist and an anticonvulsant. It is a quinoxaline derivative, an organobromine compound, a secondary amino compound and a member of phosphonic acids. It contains a CGP 78608(1+). | [in vivo]
CGP-78608 displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice[1]. |
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| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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