| Identification | Back Directory | [Name]
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+% | [CAS]
206658-92-6 | [Synonyms]
Tacrine HCl hydrate
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+% | [Molecular Formula]
C13H17ClN2O | [MDL Number]
MFCD00150067 | [MOL File]
206658-92-6.mol | [Molecular Weight]
252.74 |
| Chemical Properties | Back Directory | [Melting point ]
284-286°C (lit.) | [storage temp. ]
Store at -20°C | [solubility ]
H2O: soluble | [form ]
powder | [color ]
faint yellow | [Water Solubility ]
H2O: soluble | [InChI]
1S/C13H14N2.ClH.H2O/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H;1H2 | [InChIKey]
PXGRMZYJAOQPNZ-UHFFFAOYSA-N | [SMILES]
O.Cl.Nc1c2CCCCc2nc3ccccc13 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25-36/37/38-40 | [Safety Statements ]
22-24/25-26-36/37/39 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HS Code ]
2933998090 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Carc. 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
9-Amino-1,2,3,4-tetrahydroacridine hydrochloride hydrate is a well-known cholinesterase inhibitor commonly used in pharmacological studies. | [in vivo]
Pretreatment with Tacrine hydrochloride (hydrate) also modifies absolute levels of cocaine self-administration during reacquisition. Body weight declines approximately one-half percent over four days of treatment with intravenous Tacrine hydrochloride (hydrate). Delivery of Tacrine hydrochloride (hydrate) by osmotic pump does not alter either linear- or repeated- cocaine-induced locomotor activity. There is no significant main effect or interaction with Tacrine hydrochloride (hydrate) treatment on active lever responding during reinstatement. Post hoc comparisons indicate that rats self-administering cocaine has significantly lower alkaline phosphatase levels, relative to TTacrine hydrochloride (hydrate)- but not saline- treated rats evaluated by conditioned-place preference[2]. | [IC 50]
AChE; BChE |
| Spectrum Detail | Back Directory | [Spectrum Detail]
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%(206658-92-6)1HNMR
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%(206658-92-6)Raman
9-AMINO-1,2,3,4-TETRAHYDROACRIDINE HYDROCHLORIDE HYDRATE,99+%(206658-92-6)IR
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www.bocsci.com |
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