| Identification | Back Directory | [Name]
SL 47 | [CAS]
206991-64-2 | [Synonyms]
SL 47
SL-11047
SL 11047
CGC 11047
(Z)-N,N'-bis[3-(ethylamino)propyl]but-2-ene-1,4-diamine:tetrahydrochloride | [Molecular Formula]
C14H33ClN4 | [MOL File]
206991-64-2.mol | [Molecular Weight]
292.9 |
| Hazard Information | Back Directory | [Uses]
PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities[1][2]. | [References]
[1] Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77. DOI:10.1186/1741-7015-7-77
[2] Murray Stewart T, et al. A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. Cancer Chemother Pharmacol. 2021 Jan;87(1):135-144. DOI:10.1007/s00280-020-04201-1 |
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| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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