| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO:56.25(Max Conc. mg/mL);92.79(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.25(Max Conc. mM) | [form ]
A solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SRT3025 Hydrochloride is a SIRT1 activator which in turn inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages. Decreases osteoclast-mediated bone resporption. | [Biological Activity]
SRT3025 is an orally active sirtuin 1 activator (Sirt1 EC1.5 ≤1 μMEmax ≥150% and <300%) th at reduces cellular acetylation of Sirt1 substrates FoxO1 (induced by RANKL ) and histone 3 (1-10 μM; murine bone marrow macrophages) and exhibits in vivo efficacy in a murine atherosclerosis model (3.18 g/kg high-cholesterol diet; mice) and ovariectomy-induced bone loss in female mice (50 & 100 mg/kg via daily p.o.). | [IC 50]
SIRT1: 1 μM (EC1.5) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|