ChemicalBook--->CAS DataBase List--->2072057-17-9

2072057-17-9

2072057-17-9 Structure

2072057-17-9 Structure
IdentificationBack Directory
[Name]

RG7834 (Synonyms: RO 7020322)
[CAS]

2072057-17-9
[Synonyms]

RG7834 (RO 7020322)
RG7834 (Synonyms: RO 7020322)
2H-Benzo[a]quinolizine-3-carboxylic acid, 6,7-dihydro-10-methoxy-9-(3-methoxypropoxy)-6-(1-methylethyl)-2-oxo-, (6S)-
[Molecular Formula]

C22H27NO6
[MDL Number]

MFCD31555773
[MOL File]

2072057-17-9.mol
[Molecular Weight]

401.45
Chemical PropertiesBack Directory
[Boiling point ]

578.6±50.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:100.0(Max Conc. mg/mL);249.1(Max Conc. mM)
[form ]

Solid
[pka]

5.91±0.40(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells[1].
[in vivo]

RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice[1].
RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice[1].

Animal Model:HBV-infected human liver chimeric uPA-SCID mice[1]
Dosage:4 mg/kg
Administration:Twice daily for 21 days
Result:Reduced both HBsAg and HBeAg, also decreased serum HBV DNA by 0.6 log10 in mice.
[storage]

Store at -20°C
[References]

[1] Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4. DOI:10.1021/acs.jmedchem.8b01245
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