| Identification | Back Directory | [Name]
4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU& | [CAS]
207233-90-7 | [Synonyms]
4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-D
4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&
Disodium 4,4′-diisothiocyanatostilbene-2,2′-disulfonate
DIDS, Disodium 4,4μ-diisothiocyanatostilbene-2,2μ-disulfonate
Disodium 4,4'-diisothiocyanato-2,2'-stilbenedisulphonate hydrate
4,4''-DIISOTHIOCYANATOSTILBENE-2,2''-DISULPHONIC ACID DISODIUM SALT
disodium 2,2'-(E)-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonate)
4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate
4，4'-Diisothiocyanatostilbene-2，2'-disulfonic acid disodium salt hydrate
4,4'-Diisothiocyanatostilbene-2,2'-disulphonic acid disodium salt hydrate
4,4μ-Diisothiocyanato-2,2μ-stilbenedisulfonic acid hydrate disodium salt
4,4μ-Diisothiocyanatostilbene-2,2μ-disulfonic acid hydrate disodium salt
4,4'-DIISOTHIOCYANATO-2,2'-STILBENEDISUL -FONIC ACID, DI-NA SALT XH2O TECH., 90%
4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt hydrate >=80% (elemental analysis), powder
DisodiuM 4,4'-diisothiocyanatostilbene-2,2'-disulfonate, 4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid disodiuM salt hydrate | [Molecular Formula]
C16H13N2NaO7S4 | [MDL Number]
MFCD00009638 | [MOL File]
207233-90-7.mol | [Molecular Weight]
496.52 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
0.1 M potassium bicarbonate: soluble50mg/mL | [form ]
powder | [color ]
yellow | [BRN ]
8179433 | [InChI]
1S/C16H10N2O6S4.2Na/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24;;/h1-8H,(H,19,20,21)(H,22,23,24);;/q;2*+1/p-2/b2-1+;; | [InChIKey]
GEPAYBXVXXBSKP-SEPHDYHBSA-L | [SMILES]
[Na+].[Na+].[O-]S(=O)(=O)c1cc(ccc1\C=C\c2ccc(cc2S([O-])(=O)=O)N=C=S)N=C=S |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
36/37/38-42 | [Safety Statements ]
22-26 | [WGK Germany ]
3 | [HS Code ]
29309090 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Resp. Sens. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt hydrate has been used:
- as band3 protein inhibitor in rabbits(19)
- for the inhibition of bicarbonate transporters in brain slice tissue(20)
- as HCO3-/Cl- exchanger (anion exchanger) in embryos(21)
| [reaction suitability]
reagent type: cross-linking reagent | [Biochem/physiol Actions]
4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is an anionic alkylating agent containing isothiocyanate residue. It is a negatively charged homobifunctional cross-linking reagent. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid is a specific inhibitor of cellular anion permeability used in cell transport studies. The isothiocyanate groups react with primary amines at pH 9.0-10.0. 4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid alkylates lysine residues and inhibits apoptosis indirectly by targeting membrane based anion transporters.In addition, it also inhibits calcium transport in vesicles. |
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