| Identification | Back Directory | [Name]
Saikosaponin A | [CAS]
20736-09-8 | [Synonyms]
SAIKOSAPONIN A
Saikosaponian A
SAILKOSAPONIN A
SAILKOSAPONINS A
Thesaikosaponin A
SAIKOSAPONIN A(RG)
Saikosaponin a std.
SABINYL ACETATE(RG)
dihydroxyolean-11-en-3-yl6-deoxy-3-O-β-D-
β-D-fucoside, (3β,4α,16β)-13,28-epoxy-16,23-
Saikosaponin A, 98%, from Bupleurum chinense DC.
[(4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3β-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
[(3β,4R)-13,28-Epoxy-16β,23-dihydroxyolean-11-en-3-yl]3-O-(β-D-glucopyranosyl)-6-deoxy-β-D-galactopyranoside
(3beta,4alpha,16beta)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl-6-deoxy-3-O-beta-D-glucopyranosyl-beta-D-galactopyranoside | [EINECS(EC#)]
244-001-6 | [Molecular Formula]
C42H68O13 | [MDL Number]
MFCD00075675 | [MOL File]
20736-09-8.mol | [Molecular Weight]
780.98 |
| Chemical Properties | Back Directory | [Melting point ]
225～232℃ (dec.) | [Boiling point ]
893.7±65.0 °C(Predicted) | [density ]
1.163～1.168 g/ml | [refractive index ]
1.571～1.574 (20/D) | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly) | [form ]
Solid | [pka]
12.83±0.70(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChIKey]
KYWSCMDFVARMPN-FMIBPMOUSA-N | [CAS DataBase Reference]
20736-09-8 |
| Hazard Information | Back Directory | [Uses]
Saikosaponin A was shown to exhibit anti-inflammatory activities by suppressing activation of NF-kB signaling pathway. | [Chemical Properties]
Pale yellow crystals, easily soluble in water and dilute alcohol, difficult to dissolve in benzene, ether and chloroform, derived from the aerial parts of Bupleurum chinense. | [Definition]
ChEBI: Saikosaponin A is a saikosaponin. | [in vivo]
Saikosaponin A (1-10 mg/kg, i.p, 7 d) attenuates the morphological changes in the small intestine induced by 5-FU[2].
Saikosaponin-A (1-10 mg/kg, i.p, 7 d) enhances the decrease of antioxidant enzymes in intestinal tissue caused by 5-FU[2].
| Animal Model: | 5-FU (HY-90006)-induced mucositis in BALB/c mice modle[2] | | Dosage: | 1, 5, 10?mg/kg/day, 7 d | | Administration: | injected intraperitoneally (i.p) | | Result: | Reduced villus blunting, crypt cells apoptosis, and inflammatory cell infiltration.
Decreased concentration of GSH, GST, Catalase, and SOD in intestinal tissue.
|
| [storage]
-20°C, protect from light |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|