| Identification | Back Directory | [Name]
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE | [CAS]
207857-15-6 | [Synonyms]
207857-15-6
Goodman's Reagent
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)-
N N'-BIS(TERT-BUTOXYCARBONYL)-N -TRIFLY&
1,3-DI-BOC-2-(TRIFLUOROMETHYLSULFONYL)GUANIDINE
n,n'-bis(tert-butoxycarboyl)-n''-trifylguanidine
1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine
N,N'-BIS(TERT-BUTOXYCARBONYL)-N''-TRIFLYLGUANIDINE
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine ,98%
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine (~90%)
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine≥ 98% (HPLC)
1,3-Di-Boc-2-(trifluoroMethylsulfonyl)guanidine,>=95.0%(HPLC)
dimethylethoxycarbonyl)-N''-(trifluoromethylsulfonyl)guanidine
2-[(Trifluoromethyl)sulphonyl]guanidine, 1,3-Bis-BOC protected
tert-butyl {(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]...
Tert-Butyl N-[N-tert-butoxycarbonyl-N'-(trifluoromethylsulfonyl)
1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
2-[(Trifluoromethyl)sulphonyl]guanidine, 1,3-Bis-BOC protected 95%
1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine
N,N'-Bis(tert-butoxycarbonyl)-N''-(trifluoromethanesulfonyl)guanidine
N,N'-Bis(1,1-dimethylethoxycarbonyl)-N''-(trifluoromethylsulfonyl)guanidine
tert-Butyl N-N-tert-butoxycarbonyl-N'-(trifluoromethylsulfonyl)carbamimidoylcarbamate
tert-Butyl [(tert-butoxycarbonyl)amino]{[(trifluoro-methyl)sulfonyl]imino}methylcarbamate
Carbamic acid, [[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, bis(1,1-dimethylethyl)ester
tert-Butyl {N-(tert-butoxycarbonyl)-N'-[(trifluoromethyl)sulphonyl]carbamimidoyl}carbamate
tert-butyl N-({[(tert-butoxy)carbonyl]amino}(trifluoromethanesulfonylimino)methyl)carbamate
ert-butylN-[N-[(2-methylpropan-2-yl)oxycarbonyl]-N'-(trifluoromethylsulfonyl)carbamimidoyl]carbamate
Carbamic acid, N,N'-[[(trifluoromethyl)sulfonyl]carbonimidoyl]bis-, C,C'-bis(1,1-dimethylethyl) ester
tert-butyl {(tert-butoxycarbonyl)[(trifluoromethyl)sulfonyl]carbamimidoyl}carbamate (non-preferred name)
1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethanesulfonyl)guanidine (This product is only available in Japan.)
1,3-Bis(tert-butoxycarbonyl)-2-(trifluoroMethanesulfonyl)guanidine (This product is only available for selling doMestically in Japan)
1,3-Di-Boc-2-(trifluoromethanesulfonyl)guanidine
1,3-Bis(tert-butoxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine
1,3-Di-Boc-2-(trifluoromethylsulfonyl)guanidine
Goodman's Reagent | [Molecular Formula]
C12H20F3N3O6S | [MDL Number]
MFCD02683528 | [MOL File]
207857-15-6.mol | [Molecular Weight]
391.36 |
| Chemical Properties | Back Directory | [Melting point ]
113 °C (dec.)(lit.)
| [density ]
1.36 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Acetonitrile, Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
-4.76±0.40(Predicted) | [color ]
White to Off-White | [BRN ]
7947176 | [InChI]
InChI=1S/C12H20F3N3O6S/c1-10(2,3)23-8(19)16-7(17-9(20)24-11(4,5)6)18-25(21,22)12(13,14)15/h1-6H3,(H2,16,17,18,19,20) | [InChIKey]
GOQZIPJCBUYLIR-UHFFFAOYSA-N | [SMILES]
C(/NC(=O)OC(C)(C)C)(=N\C(=O)OC(C)(C)C)\NS(=O)(=O)C(F)(F)F |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
Guanidinylation reagents for amines and peptides | [Synthesis]
N,N'-Bis(tert-butoxycarbonyl)guanidine (S6; 4.38 g, 16.9 mmol, 1.00 eq.) was dissolved in dichloromethane (CH2Cl2, 84.4 mL) at room temperature. The reaction mixture was cooled to -78°C and stirred for 10 minutes. Subsequently, freshly distilled triethylamine (Et3N; 1.79 g, 17.7 mmol, 1.05 eq.) was added slowly and dropwise. Trifluoromethanesulfonic anhydride (5.00 g, 17.7 mmol, 1.05 eq.) was added dropwise over 15 min at -78 °C while maintaining vigorous stirring. The reaction mixture was gradually warmed up to room temperature. After 6 hours of reaction, the reaction mixture was washed with 1.0 M potassium bisulfate (KHSO4) solution followed by water (H2O). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and filtered. The solvent was removed by concentration under reduced pressure. Purification by silica gel fast column chromatography (eluent: 100% dichloromethane) afforded 1,3-di-BOC-2-(trifluoromethylsulfonyl)guanidine (S7; 5.51 g, 14.1 mmol, 83% yield) as a colorless solid. | [References]
[1] Journal of Organic Chemistry, 2001, vol. 66, # 3, p. 1038 - 1042
[2] Organic Syntheses, 2002, vol. 78, p. 91 - 91
[3] Journal of Organic Chemistry, 1998, vol. 63, # 12, p. 3804 - 3805
[4] Journal of Organic Chemistry, 1998, vol. 63, # 23, p. 8432 - 8439
[5] ChemMedChem, 2014, vol. 9, # 1, p. 129 - 150 |
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