| Identification | Back Directory | [Name]
H-ARG-SER-ARG-THR-ARG-GLN-PHE-TYR-GLY-LEU-MET-NH2 | [CAS]
208041-90-1 | [Synonyms]
HK-1, MOUSE
HEMOKININ-1
HEK-1, MOUSE
HK-1 (MOUSE, RAT)
HEK-1 (MOUSE, RAT)
HEMOKININ 1 (MOUSE)
H2N-RSRTRQFYGLM-AMIDE
HEMOKININ 1 MOUSE?, >98%
HEMOKININ 1 (MOUSE, RAT)
Hemokinin 1 mouse,RSRTRQFYGLM, >98%
HK-1 (Mouse, rat), HEK-1 (Mouse, rat)
ARG-SER-ARG-THR-ARG-GLN-PHE-TYR-GLY-LEU-MET-NH2
H-ARG-SER-ARG-THR-ARG-GLN-PHE-TYR-GLY-LEU-MET-NH2
HeMokinin 1 (Mouse, rat)
HK-1 (Mouse, rat), HEK-1 (Mouse, rat)
TACHYKININ 4 PRECURSOR (56-66) AMIDE [RATTUS NORVEGICUS]/[MUS MUSCULUS]
L-Methioninamide, L-arginyl-L-seryl-L-arginyl-L-threonyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl- | [Molecular Formula]
C61H100N22O15S | [MDL Number]
MFCD06659096 | [MOL File]
208041-90-1.mol | [Molecular Weight]
1413.65 |
| Chemical Properties | Back Directory | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
H2O: soluble | [form ]
powder | [pka]
9.82±0.15(Predicted) | [color ]
white | [Water Solubility ]
Soluble to 2 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively. | [in vivo]
Hemokinin 1 (mouse) (0.01-100 nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10 nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2 nmol/kg (0.1-0.4 nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1 nmol/kg (0.07-0.2 nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100 nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats[1]. | [IC 50]
NK1 | [storage]
Store at -20°C | [References]
[1] Francesca Bellucci, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br J Pharmacol. 2002 Jan; 135(1): 266-274 |
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