| Identification | Back Directory | [Name]
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE | [CAS]
20869-95-8 | [Synonyms]
ERMANIN
NSC 31882
3,4'-Dimethoxykaempferol
KAEMPFEROL-3,4'-DIMETHYL ETHER
Kaempferol 3,4'-di-O-methyl ether
5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE
3,4'-DIMETHOXY-5,7-DIHYDROXYFLAVONE
5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4-benzopyrone
5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
5,7-Dihydroxy-3-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-methoxy-2-(4-methoxyphenyl)- | [EINECS(EC#)]
244-093-8 | [Molecular Formula]
C17H14O6 | [MDL Number]
MFCD00017440 | [MOL File]
20869-95-8.mol | [Molecular Weight]
314.29 |
| Chemical Properties | Back Directory | [Melting point ]
234 °C | [Boiling point ]
552.0±50.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [solubility ]
DMF: 20 mg/ml
DMSO: 15 mg/ml | [pka]
6.32±0.40(Predicted) | [LogP]
2.400 (est) |
| Hazard Information | Back Directory | [Uses]
Ermanin is a useful research chemical used in HIV-1 integrase inhibition. Ermanin exhibits actioxidant properties against peroxyl and hydroxyl radicals. | [Definition]
ChEBI: 3,4'-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. It has a role as an anti-inflammatory agent, an antimycobacterial drug, an apoptosis inducer, an antineoplastic agent and a plant metabolite. It is a dihydroxyflavone and a dimethoxyflavone. It is functionally related to a kaempferol. | [IC 50]
iNOS; Bacterial; COX-2 | [References]
[1] QIONG DING . The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis[J]. Free Radical Biology and Medicine, 2021, 176: Pages 392-405. DOI: 10.1016/j.freeradbiomed.2021.09.017
[2] JOSÉ ANTONIO GUERRA. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum[J]. International immunopharmacology, 2006, 6 11: Pages 1723-1728. DOI: 10.1016/j.intimp.2006.08.012
[3] NADINE DE MEYER. 4’-Hydroxy-3-methoxyflavones with potent antipicornavirus activity[J]. Journal of Medicinal Chemistry, 1991, 34 2: 736-746. DOI: 10.1021/jm00106a039 |
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BioBioPha Co., Ltd.
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http://www.biobiopha.com |
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