| Identification | Back Directory | [Name]
(5-METHOXY-2-NITRO-PHENYL)-ACETIC ACID | [CAS]
20876-29-3 | [Synonyms]
5-Methoxy-2-nitrobenzeneacetic acid
2-(5-methoxy-2-nitrophenyl)aceticaci
(5-METHOXY-2-NITRO-PHENYL)-ACETIC ACID
Benzeneacetic acid, 5-Methoxy-2-nitro-
(5-Methoxy-2-nitro-phenyl)-acetic acid ,97% | [Molecular Formula]
C9H9NO5 | [MDL Number]
MFCD00047735 | [MOL File]
20876-29-3.mol | [Molecular Weight]
211.17 |
| Chemical Properties | Back Directory | [Melting point ]
176 °C | [Boiling point ]
404.7±30.0 °C(Predicted) | [density ]
1.382±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
3.83±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of the American Chemical Society, 77, p. 670, 1955 DOI: 10.1021/ja01608a039 | [Synthesis]
General procedure for the synthesis of 2-nitro-5-methoxyphenylacetic acid from 5-methoxy-2-nitrophenylacetonitrile: 1 equivalent of 5-methoxy-2-nitrophenylacetonitrile was dissolved in a mixture of acetic acid (AcOH) and concentrated hydrochloric acid (HCl) (1:5, v/v), and the reaction mixture was heated for 4 hr under reflux conditions. Upon completion of the reaction, the target product 2-nitro-5-methoxyphenylacetic acid was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate (Na2SO4), followed by removal of solvent by rotary evaporator to give the product. | [References]
[1] Tetrahedron Letters, 2014, vol. 56, # 1, p. 89 - 94
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 4, p. 1482 - 1496 |
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