| Identification | Back Directory | [Name]
CAQK peptide | [CAS]
2088281-24-5 | [Synonyms]
CAQK peptide
Cys-Ala-Glu-Lys
L-Lysine, L-cysteinyl-L-alanyl-L-glutaminyl- | [Molecular Formula]
C17H32N6O6S | [MOL File]
2088281-24-5.mol | [Molecular Weight]
448.54 |
| Chemical Properties | Back Directory | [Boiling point ]
913.554±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.299±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
3.271±0.10(predicted) | [color ]
White to off-white | [Sequence]
Cys-Ala-Glu-Lys |
| Hazard Information | Back Directory | [Uses]
CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier[1][2]. | [in vivo]
CAQK (100 nmoles/100 μL into the tail vein; at 24 h or 5 days post-injury) homes to lysolecithin-induced focal lesions in the spinal cord. | Animal Model: | C57BL/6J 8-week-old male mice[1] | | Dosage: | 100 nmoles/100 μl in PBS | | Administration: | Tail vein; at 24 h or 5 days post-injury (focal demyelination was induced by stereotaxic injection of 1 μL of 1% lysolecithin solution into the right ventral) | | Result: | Caused the accumulation of peptide at the injury site by an increased density of mononucleated DAPI+ cells and fragmented myelin stained for myelin basic protein.
The peptide was not detected in the spinal cords of control sham-operated (PBS injected) mice showing regular densities of DAPI+ cells.
|
| [References]
[1] Charly Abi-Ghanem, et al. CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries. Front Cell Neurosci. 2022 Aug 22:16:908401. DOI:10.3389/fncel.2022.908401
[2] Aman P Mann, et al. A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun. 2016 Jun 28:7:11980. DOI:10.1038/ncomms11980 |
|
|