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CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease[1]. | [References]
[1] Shapiro L, et al. Alpha-1-antitrypsin inhibits human immunodeficiency virus type 1. FASEB J. 2001 Jan;15(1):115-122. DOI:10.1096/fj.00-0311com |
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